In recent years, graphene oxide(GO) -based composite materials have been increasingly used in biomedical field. Compared with pure GO, GO-based composite materials have better biological safety while achieving more stable antibacterial properties. In this paper, research status and related application in antibacterial field of GO-based composite materials is reviewed from the aspects of antibacterial mechanism and biosafety, so as to provide reference for the development and application of GO-based composite materials in antibacterial field.