In order to cope with epidemic of coronavirus disease 2019(COVID-19), guide the prevention and control infection in all parts of the country, national health administrative departments and relevant industry organizations have successively issued relevant regulations, but there are some differences in regulation norms, which inevitably confuses health care workers. Therefore, this paper compares and analyses the domestic regulations from the aspects of origin of regulations, the environmental cleaning and disinfection regulations, and the use of personal protective equipment for health care workers.