Retrospective analysis was performed on the successful treatment of a patient with severe coronavirus disease 2019(COVID-19), suggesting that for COVID-19 patients, antiviral and anti-inflammatory treatment should be given in time at the early stage of onset, and respiratory support treatment should be given in time when oxyge-nation drops. When oxygenation index of acute respiratory distress syndrome decreases progressively and effect of nasal high-flow oxygen therapy is not ideal, early combination of prone position ventilation treatment is crucial to the improvement of successful treatment rate of severe patients, at the same time, it can avoid mechanical ventilation and reduce mortality.