Objective To investigate the core emergency response competence(CERC) of health care workers (HCWs) in Chongqing in the face of coronavirus disease 2019(COVID-19), and analyze the influence factors for emergency response competence in the face of COVID-19. Methods Convenient sampling method was adopted, questionnaire was designed according to HCWs' CERC system for infectious diseases, HCWs' CERC for COVID-19 in Chongqing was investigated and analyzed. Results A total of 725 valid questionnaires of HCWs were collected, score of CERC for COVID-19 was (128.14±25.38), multiple linear regression analysis showed the main influencing factors for CERC of HCWs were age,professional qualifications,job categories, hospital level,whether departments ever attended the training related to COVID-19. Conclusion HCWs' CERC for COVID-19 in Chongqing is at intermediate-level, training should be conducted according to different age,professional qualifications, job categories and departments, emergency drilling needs to be strengthened, so as to improve HCWs' CERC in the face of infectious disease emergent event.