Objective To explore the relationship between human immunodeficiency virus (HIV) infection and onset risk of heart failure(HF). Methods PubMed, Embase, Chinese Biomedical Literature Database, China National Knowledge Infrastructure(CNKI), Wanfang Database, and VIP Database were searched,the published prospective cohort studies on HIV infection and onset risk of HF were collected, Meta-analysis was conducted with Stata 12.0 software, pooled hazard ratio (HR) and corresponding 95% confidence interval(CI) was calculated. Results Five studies were included, 84 557 were in HIV infection exposed group and 219 177 in non-HIV infection exposed group. Meta-analysis showed that HIV infection may increase the onset risk of HF by 48%(HR=1.48,95%CI:1.31-1.67,P<0.001); subgroup analysis was conducted according to HIV-1 RNA viral load, CD4⁺ cell count and source of population in the study, results showed that the heterogeneity of this study may be due to veterans group in the study population. Conclusion HIV infection may be one of risks of onset of HF, which may increase onset risk of HF.