Objective To review the hot spots in healthcare-associated infection(HAI) control electronic information service system in China in recent 10 years, and summarize the trend changes of hot spots of HAI management personnel. Methods Based on the python scrapy programming method, this paper captured the content published in the Shanghai International Forum for Infection Control(SIFIC) form April 6, 2007 to December 31, 2017, processed Chinese word segment, and extracted the top 5 available words as hot words for analysis. Results A total of 3 112 840 data from 93 sections of SIFIC from 2007 to 2017 were obtained. According to the annual longitudinal analysis, the top 3 hot words were "disinfection", "monitoring", and "training". In 2009, the global outbreak of novel influenza A (H1N1), "influenza A" became the first hot spot word of the year; in 2017, 10 new regulations for HAI management were officially implemented, and "regulation" became the second hot spot word of the year. From horizontal perspective of key sections, each professional section has its own different focus direction, showing the complexity and diversity of HAI management discipline. Conclusion Through the hot spot analysis on the electronic information service system in the field of HAI control, changing trend of focus in the field of practical work can be understood, the focus on hot issues can be further improved and HAI control ability can be improved.