Objective To analyze epidemiological and clinical characteristics of novel coronavirus (2019-nCoV) infection in patients in fever clinic, understand the causes and clinical manifestations of fever, and povide basis for disease prevention and treatment. Methods Medical records of patients with fever in fever clinic of a large general hospital from January 17 to February 2, 2020 were analyzed, including general information, epidemiological history, 2019-nCoV nucleic acid test and other laboratory test results. Results There were 1 770 patients, 888 were males and 882 were females, 61.24% of whom were aged 21-40 years. Laboratory examination showed 2019-nCoV nucleic acid test was positive in 15 patients, mainly white blood cell count was normal or decreased, lymphocyte count decreased, accounted for 100.00% and 40.00% respectively. Of 857 chest CT scan reports, 822(95.92%) were positive. Conclusion Setting up fever clinic is conducive to the rapid and effective screening of fever patients, virus infection is most common among patients in fever clinic, mainly young and middle-aged people, positive of chest CT examination is high in patients with positive of 2019-nCoV nucleic acid test.