Objective To assess the method and efficacy of infection risk management of a medical team which rush to the rescue of Wuhan. Methods During the epidemic period of coronavirus disease 2019 (COVID-19), one health care worker was infected with COVID-19 in a designated hospital, a Wuhan medical team which rushed to the rescue of this hospital sought risk points through risk identification, assessed the risk of team members by online questionnaire tool, and took countermeasures against risk according to risk assessment results. Results Through sorting out the work and life process of health care workers in medical team, exposure risk identification form was formulated. Online questionnaire was used to evaluate the risk of team members, and 4 team members were found to have exposure risk. 4 team members were interviewed again, judged comprehensively, and all were excluded from high risk exposure, infection prevention and control measures were strengthened. After 14 days of observation, by the end of February 22, none of the medical team members had been infected. Conclusion During the epidemic period, management on risk can effectively control the risk of infection.