Objective To understand the diagnosis, treatment and infection route of a case of severe fever with thrombocytopenia syndrome(SFTS), provide basis for formulating its prevention and control strategy. Methods The case was performed field epidemiological and seroepidemiological investigation. Results Patient was diagnosed with SFTS according to epidemiological history, clinical manifestations, and laboratory examination results. Prior to the illness onset, patient had a history of fluid contact with confirmed case of SFTS in Hubei Province, no tick was found in epidemic regions, and no other cases were found through case search. Conclusion The patient is the first confirmed case of SFTS in Guangdong Province, and the source of infection is from Hubei Province.