The American Society of Health-System Pharmacists Midyear Clinical Meeting (ASHP Midyear) is one of the largest pharmaceutical meeting in the world, featuring as reporting international advanced clinical pharmaceutical research, which puts forward innovative and scientific suggestions aiming at hotspots and difficulties in the field of hospital pharmacy. At the recent ASHP Midyear meeting held in December 2019, anti-infective therapy and antimicrobial stewardship remained a focus, meaningful contents were issued, referring to bacteremia, methicillin-resistant Staphylococcus aureus (MRSA), Clostridium difficile, penicillin allergy and antimicrobial stewardship program (ASP) in medical institutions, these are also hotspots in the field of anti-infection in domestic hospitals. This paper shares the enlightenment and feelings of the participants, and introduces the ASP carried out in the author's hospital.