China began to carry out healthcare-asssociatd infection (HAI) prevention and control since 1985, HAI prevention and control professionals have made great contribution to infection prevention and control since the national comprehensive implementation of HAI prevention and control. As one of the earliest full-time professionals in the prevention and control of HAI in China, the author summarizes the early practical exploration on HAI prevention and control in China through his own practical experience combined with literature analysis, 10 typical cases were listed, aiming to provide reference for the prevention and control of HAI in China.