艰难梭菌与抗生素相关腹泻的研究进展
作者:
作者单位:

1.湖南中医药大学, 湖南 长沙 410208;2.湖南中医药大学药学院食品药品工程系, 湖南 长沙 410208

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肖嫩群  E-mail : xiaonenqun@.sohu.com

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+2;R516]]>

基金项目:

湖南省自然科学基金(2020JJ4468);湖南中医药大学生物工程重点学科资助(校行科字[2018]3号)


Advances in Clostridium difficile and antibiotic-associated diarrhea
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Affiliation:

1.Hunan University of Chinese Medicine, Changsha 410208, China;2.Department of Food and Drug Engineering, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China

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    摘要:

    抗生素相关性腹泻(AAD)是指应用抗生素后发生的、与抗生素有关的腹泻,是常见的药物不良反应,其发病机制并未完全阐明。艰难梭菌(CD)是一种具有芽孢结构厌氧的肠道致病菌,被认为是引起AAD的常见原因,越来越多研究表明AAD与艰难梭菌感染(CDI)相关,但CD致AAD的作用机制尚不十分明确。本文通过阐明AAD与CD的关系,并从多个方面分析CD致AAD可能作用机制以及目前存在的一些相关治疗方法,以期改进AAD的治疗与预防。

    Abstract:

    Antibiotic-associated diarrhea (AAD) refers to the diarrhea related to antibiotics after the application of antibiotics, it is a common adverse drug reaction, and its pathogenesis has not been fully elucidated. Clostridium difficile (CD) is an anaerobic enteropathogen with spore structure, which is considered to be a common cause of AAD, more and more studies have shown that AAD is related to CD infection (CDI), but the mechanism of CD-induced AAD is not very clear. This paper elucidates the relationship between AAD and CD, analyzes the possible mechanism of CD-induced AAD and some currently existing treatment methods from multiple aspects, so as to improve the treatment and prevention of AAD.

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引用本文

朱佳源,谭周进,郑淘,等.艰难梭菌与抗生素相关腹泻的研究进展[J]. 中国感染控制杂志,2021,(12):1168-1173. DOI:10.12138/j. issn.1671-9638.20218073.
Jia-yuan ZHU, Zhou-jin TAN, Tao ZHENG, et al. Advances in Clostridium difficile and antibiotic-associated diarrhea[J]. Chin J Infect Control, 2021,(12):1168-1173. DOI:10.12138/j. issn.1671-9638.20218073.

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  • 收稿日期:2021-04-21
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  • 在线发布日期: 2024-04-26
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