Objective To explore the application efficacy of the predictive three-level material management mode in the ward of coronavirus disease 2019 (COVID-19) in medical team assisting Hubei Province. Methods The predictive three-level material management mode was adopted to manage the medical materials of the third batch of Xinjiang medical teams assisting Hubei Province, timeliness rate of material taken, material redundancy rate, material handover time, and the time for one-time preparation of materials for diagnosis and treatment before and after the implementation of the management mode was compared. Results After the implementation of predictive three-level material management mode, timeliness rate of material taken enhanced, material redundancy rate decreased in each region, differences were both statistically significant (both P < 0.05); material handover time, time required for item preparation for blood collection and oxygen inhalation was shorter than before implementation, satisfaction of health care workers was higher than before implementation (80.13% vs 96.15%), differences were all statistically significant (all P < 0.05). Conclusion The predictive three-level material management model can strengthen the prospective treatment strategy, achieve precise and scientific management on materials in COVID-19 ward, effectively improve the management efficiency of aid materials in Hubei Province, achieve the satisfaction of both doctors and nurses, which is worth promoting and applying.