The symptoms of Strongyloides stercoralis infection are mild and difficult to be found in the early stage, which is prone to result in missed diagnosis and misdiagnosis, and cause severe complications even death if not treated in time. One patient had recurrent gastrointestinal symptoms, effect was poor after symptomatic treatment, during admission examination, it was found that there was co-infection of Strongyloides stercoralis and Clonorchis sinensis. This paper reports about this case as well as literature review, aiming to deepen the understan-ding of characteristics of Strongyloides stercoralis infection, provide more basis for clinical diagnosis and treatment.