Inhaled glucocorticoids (ICS) is widely used in the treatment of patients with chronic obstructive pulmonary disease (COPD), but long-term use of ICS is prone to various infections due to local immunosuppression. Three patients with COPD and pulmonary tuberculosis were admitted in department of respiratory and critical care medicine of a hospital in 2015, 2019 and 2021 respectively. According to medical history and relevant examination, pulmonary tuberculosis might be related to ICS. This article intends to analyze the diagnosis and treatment process of 3 cases of ICS-related pulmonary tuberculosis in this hospital, combined with existing research to discuss the diagnosis and treatment strategy of patients with COPD and ICS-related pulmonary tuberculosis.