Objective To analyze the changing trend of disease burden and epidemic situation of hepatitis C in China from 1990 to 2019, and provide scientific basis for promoting the elimination of hepatitis C. Methods Data of the Global Burden of Disease Study 2019 (GBD 2019) were used to analyze the 30-year changing trend and current situation of the occurrence, onset, disability-adjusted life year (DALY) and years of life lost (YLL) of hepatitis C in Chinese population, GraphPad Prism 8.0 was used for mapping. Results In 2019, standardized DALY rate of the total disease burden of hepatitis C in China was about 101/100 000 person-year; the standardized incidence of acute hepatitis C was about 47/100 000; the peak incidence of hepatitis C-related chronic liver disease was in population of 40-44 years old, and standardized morbidity was about 1 247/100 000. From 1990 to 2019, the total standardized incidence and standardized morbidity of hepatitis C dropped to the trough in 2015, and then rose sharply in the following 4 years; standardized DALY rate has been declining for 30 years. Conclusion Hepatitis C-related chronic liver disease is the main disease burden of hepatitis C; due to the short treatment cycle and good efficacy of direct antiviral drugs, it is recommended to strengthen publicity, strengthen hepatitis C screening, and promote the construction of a healthy China.