Hand-foot-and-mouth disease (HFMD) is an acute infectious disease mainly caused by enterovirus infection and is easy to invade skin and mucosa of children's hands, feet, and mouth, reports of adult infection are not rare in recent years. There are some differences in epidemiology and clinical features of HFMD between adults and children. Domestic and foreign scholars have carried out relevant research on the epidemic and clinical features of adult HFMD, this paper summarizes the current research progress on the epidemiology and clinical features of adult HFMD.