Clostridioides difficile infection (CDI) is a clinical problem that deserves more attention. Its clinical manifestations range from mild /moderate diarrhea to fulminant colitis, even death.At present, the first-line drugs for treating CDI mainly include metronidazole, vancomycin, etc. But because of the high recurrence rate after treatment, it is urgent to find new treatment scheme for CDI. In recent years, nutrients like protein, amino acid, carbohydrate, trace elements and plant extracts have been reported to be beneficial to the treatment of CDI.This article reviews the research on the adjuvant treatment of CDI with food-derived substances such as nutrients and plant extracts, in order to provide reference for the adjuvant treatment of CDI.