Objective To explore the application effect of group closed-loop nursing + AB role management mode on the emergency intensive care unit. Methods 65 nursing staff from a temporary intensive care unit of a hospital from December 26, 2022 to January 30, 2023 were selected as the research subjects. Group closed-loop nursing + AB role management mode was applied to the newly established emergency intensive care unit, nurses' satisfaction was surveyed with cluster sampling method, and intervention effect was valuated. Results Under this management mode, the overall satisfaction of nurses was 92.60%, the satisfaction rates of both group closed-loop nursing mode and AB role management mode were 96.30%. The incidence of catheter-associated urinary tract infection (CAUTI) in patients was 3.10‰, incidences of ventilator-associated pneumonia (VAP) and central line-associated bloodstream infection (CLABSI) were both 0. Conclusion The application of group closed-loop nursing + AB role ma-nagement mode in emergency intensive care unit optimizes the nursing management process, stimulates team's cohesion, motivates nurses, prevents the occurrence of healthcare-associated infection, thus improves the treatment and safety of patients with acute and critical diseases.