Sepsis is a life-threatening organ dysfunction resulting from dysregulated host responses to infections. Platelet-related indicators are closely related to the prognosis of sepsis, including platelet(PLT) count, mean platelet volume (MPV), platelet distribution width (PDW) and platelet aggregation rate (PAR), which can serve as important evaluation indicators for the occurrence and development of sepsis. This paper elaborates the value of platelet-related indicators in evaluating the prognosis of patients with sepsis, aiming to help clinicians understand the clinical value of monitoring platelet-related indicators in sepsis patients and accurately identify high-risk sepsis patients.