Cerebral venous sinus thrombosis (CVST) is a rare cerebrovascular disease. Intracranial infection is one of the important causes of CVST, while intracranial infection caused by Listeria monocytogenes (LM) is relatively rare in clinic. This paper reports a case of CVST secondary to LM meningitis, which was improved and discharged from hospital after anti-infection and anti-coagulation treatment, so as to provide reference for the clinical diagnosis and treatment of such patients.