The establishment of healthcare-associated infection (HAI) prevention and control emergency system for respiratory infectious diseases is the basis for large general hospitals to start emergency mechanisms smoothly and quickly in response to the outbreaks of respiratory infectious diseases, and achieve the "transformation of epidemic prevention" mode, thus can greatly reduce the risk of HAI in general hospitals during the outbreaks of respiratory infectious diseases. Based on the practical experience of the prevention and control of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, relevant standards, norms, guidelines, documents, and combined with risk assessment, this study preliminarily explores and establishes a four-level emergency management system for general hospitals to respond to HAI of respiratory infectious diseases. The emergency system consists of four-level organizational system: the emergency command center, HAI management and collaborative departments, joint inspection teams, department leaders and grid administrators. The hospital leadership is responsible for the overall deployment. The emergency command center is responsible for unified coordination. Responsibilities of each department are clearly defined, and the hospital-wide grid mechanism of the prevention and control is activated. The joint inspection team supervises the implementation of various prevention and control measures, and the hospital quickly converts to the "epidemic prevention and control" emergency status, while ensuring the orderly conduct of daily diagnosis and treatment work.