Vibrio vulnificus (V. vulnificus) is a Gram-negative, curved rod-shaped bacterium which exists in warm seawater and belongs to Halophilic vibrio. V. vulnificus can cause necrotizing fasciitis, a rare but fatal clinical emergency that is difficult to diagnose accurately in the early stages. V. vulnificus can be isolated from patient's blood, exudate, blisters and cerebrospinal fluid, which is the gold standard for clinical diagnosis of the infection. The main clinical manifestations of V. vulnificus infection included acute fever, chills, hemorrhagic bullous skin lesions, and septic shock. Appropriate antimicrobial therapy should be conducted immediately and early surgical intervention is necessary. This article reports a case of V. vulnificus infection, aiming to improve the clinical.