Objective To analyze the epidemiological characteristics of pulmonary tuberculosis (PTB) in schools in Daxing District, Beijing, from 2016 to 2021, and provide scientific evidence for PTB prevention and control in schools within this district. Methods The school-related PTB cases in Daxing District of Beijing were co-llected through the "China Disease Prevention and Control Information System-Surveillance Report Management" and the monthly report table of PTB epidemic surveillance in schools of Daxing District of Beijing from 2016 to 2021. The epidemiological characteristics were analyzed. Results A total of 446 school-related cases were reported, mostly were student cases (n=386, 86.55%). The number of reported cases decreased from 192 in 2016 to 37 in 2021, and both the number of reported cases and the proportion of student cases showed a declining trend. The male to female ratio was 2.72 ∶1, and the incidence peak was mainly distributed in April-May or September-October. The cases in low age schools (kindergartens, primary schools) were mainly teaching staff, accounting for 87.50% and 54.55%, respectively. The cases were mainly distributed in vocational schools and universities, accounting for 78.48%. The proportion of patients with negative pathogenic results was ralatively high (63.90%), but the number of patients with positive pathogenic results increased significantly after 2018. A total of three PTB clustered epidemics and one public health emergency event were reported, with 181 cases involved. Conclusion PTB epidemic in schools in Da-xing District decreased steadily from 2016 to 2021. Teaching staff were the main cases in kindergartens and primary schools, while students in vocational schools and universities were the major population for PTB prevention and control in schools. It is necessary to improve the ability of active monitoring, detect the epidemic as early as possible, so as to effectively prevent the spread of tuberculosis epidemic in schools.