Objective To clarify the responsibilities and influencing factors of infection control liaison nurses (ICLNs) in general hospitals. Methods Relevant databases were systematically retrieved with scoping review method from establishment to March 18, 2023, and the included literatures were reported standardizedly. Results A total of 36 literatures were included in the analysis. Responsibilities of ICLNs included admittance criteria, selection methods, and job responsibilities. Influencing factors of ICLNs included training, empowerment, performance evaluation, continuous improvement measures, and personnel allocation. After the establishment of ICLNs, incidence of healthcare-associated infection and detection rate of multidrug-resistant organisms were reduced, compliance rate of health care workers' hand hygiene and monitoring rate of hospital environment were improved, and the cleaning and disinfection of hospital environment was standardized. Conclusion ICLNs play a role in preventing and controlling the occurrence of healthcare-associated infection. The management and application should be further standardized and improved, the effectiveness of ICLNs needs to be thoroughly studied, so as to promote the deve-lopment of ICLNs, and improve the quality of healthcare-associated infection management.