粪菌移植在感染性疾病中的应用研究进展
作者:
作者单位:

1.江南大学附属中心医院消化内科, 江苏 无锡 214000;2.南京医科大学第二附属医院微生态医学科, 江苏 南京 210011

作者简介:

通讯作者:

张发明  E-mail: fzhang@njmu.edu.cn

中图分类号:

R515

基金项目:

国家自然科学基金面上项目(82170563);无锡市医学创新团队(胃肠病学)(CXTD2021020)


Advances in the application of fecal microbiota transplantation in infectious diseases
Author:
Affiliation:

1.Department of Gastroenterology, Jiangnan University Medical Center, Wuxi 214000, China;2.Department of Microbiota Medicine, The Second Affiliated Hospital of Nanjing Medical University, Nanjing 210011, China

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    摘要:

    肠道菌群在机体抵御感染性疾病过程中发挥了重要作用。粪菌移植作为重建肠道菌群的重要方法,主要包括洗涤菌群移植、经内镜肠道植管术和孢子群移植。中国国家标准化管理委员会于2022年发布《关于洗涤粪菌质量控制和粪菌样本分级》的技术标准,旨在减少与粪菌移植相关的不良事件,提高患者及医技人员对粪菌移植的接受度。粪菌移植在治疗艰难梭菌复发感染领域取得成功后,在其他感染性疾病治疗的应用也成为全球研究热点。本文就粪菌移植的发展现状及其在各类感染性疾病应用的研究进展进行综述。

    Abstract:

    Intestinal flora plays an important role in the process of resisting infectious diseases. Fecal microbiota transplantation (FMT) is an important method for reconstructing intestinal microbiota, mainly includes washed microbiota transplantation, transendoscopic enteral tubing, and spore group transplantation. In 2022, the Standardization Administration of China released the technical standards for Quality control of fecal microbiota washing and grading of fecal microbiota specimens, aiming to reduce adverse events related to FMT and improve the acceptance of FMT by patients and medical personnel. After the success of FMT in the treatment of recurrent Clostridioides difficile infection, its application in the treatment of other infectious diseases has also become a global research hotspot. This paper reviews the development of FMT and its application in various infectious diseases.

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引用本文

李晶莹,陆高辰,张发明.粪菌移植在感染性疾病中的应用研究进展[J]. 中国感染控制杂志,2024,23(3):377-384. DOI:10.12138/j. issn.1671-9638.20243632.
Jing-ying LI, Gao-chen LU, Fa-ming ZHANG. Advances in the application of fecal microbiota transplantation in infectious diseases[J]. Chin J Infect Control, 2024,23(3):377-384. DOI:10.12138/j. issn.1671-9638.20243632.

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  • 收稿日期:2023-05-28
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  • 在线发布日期: 2024-04-28
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