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湖南省细菌耐药监测网2012—2021年葡萄球菌属细菌耐药性监测报告
作者:
作者单位:

1.长沙市第一医院检验科;2.中南大学湘雅三医院检验科;3.中南大学湘雅医院医院感染控制中心;4.湖南省细菌耐药监测网办公室;5.国家老年疾病临床医学研究中心(湘雅医院);6.浏阳市中医医院检验科;7.中南大学湘雅医院检验科;8.湘潭市中心医院检验科;9.湖南中医药大学第一附属医院医学检验与病理中心;10.长沙市中心医院检验科;11.张家界市人民医院检验科;12.郴州市第一人民医院检验医学中心;13.湖南省医院感染管理质量控制中心

作者简介:

通讯作者:

胡金伟  E-mail: cshujinwei@163.com
曾翠  E-mail: 39037835@qq.com

中图分类号:

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基金项目:

长沙市卫生健康委员会科研立项课题(KJ-B2023050)


Antimicrobial resistance of Staphylococcus spp.: surveillance report from Hunan Province Antimicrobial Resistance Surveillance System, 2012-2021
Author:
Affiliation:

1.Department of Laboratory Medicine, The First Hospital of Changsha, Changsha 410005, China;2.Department of Laboratory Medicine, The Third Xiangya Hospital of Central South University, Changsha 410013, China;3.Center for Healthcare-associated Infection Control, Xiangya Hospital, Central South University, Changsha 410008, China;4.Hunan Province Antimicrobial Resistance Surveillance System Office, Changsha 410008, China;5.National Clinical Research Center for Geriatric Disorders [Xiangya Hospital], Changsha 410008, China;6.Department of Laboratory Medicine, Liuyang Traditional Chinese Medicine Hospital, Liuyang 410300, China;7.Department of Laboratory Medicine, Xiangya Hospital, Central South University, Changsha 410008, China;8.Department of Laboratory Medicine, Xiangtan Central Hospital, Xiangtan 411100, China;9.Medical Laboratory and Pathology Center, The First Hospital of Hunan University of Chinese Medicine, Changsha 410011, China;10.Department of Laboratory Medicine, Changsha Central Hospital, Changsha 410004, China;11.Department of Laboratory Medicine, Zhangjiajie People's Hospital, Zhangjiajie 427000, China;12.Center for Laboratory Medicine, The First People's Hospital of Chenzhou, Chenzhou 423000, China;13.Hunan Provincial Healthcare-associated Infection Management Quality Control Center, Changsha 410008, China

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    摘要:

    目的 了解2012—2021年湖南省临床标本分离病原菌中葡萄球菌属的分布及耐药性, 为临床抗菌药物合理应用, 以及制定和评价抗菌药物临床应用管理政策提供科学依据。 方法 按照全国细菌耐药监测网(CRASS)技术方案, 应用WHONET 5.6软件对2012—2021年湖南省细菌耐药监测网上报的葡萄球菌属耐药性进行分析。 结果 2012—2021年, 葡萄球菌属中分离稳居前4位的细菌分别为金黄色葡萄球菌、表皮葡萄球菌、溶血葡萄球菌和人葡萄球菌。葡萄球菌属标本来源以痰、血、分泌物、伤口脓液和尿为主, 其中痰标本占25.4%~31.8%, 血标本占21.9%~27.8%。在所有临床分离的细菌中, 葡萄球菌属占比为15.5%~22.4%, 呈现缓慢下降的趋势。10年来, 耐甲氧西林金黄色葡萄球菌(MRSA)检出率有所下降, 从35.1%下降至24.8%, 同时耐甲氧西林凝固酶阴性葡萄球菌(MRCNS)检出率有所上升, 但是仍保持在70%以内。葡萄球菌属细菌对万古霉素、替考拉宁和利奈唑胺的敏感率为100%。 结论 湖南省临床分离葡萄球菌属细菌中, MRSA检出率有所下降, 未发现对万古霉素、替考拉宁和利奈唑胺耐药的葡萄球菌属细菌。应继续加强抗菌药物合理应用的管理及医院感染防控, 做好细菌耐药监测工作。

    Abstract:

    Objective To understand the distribution and antimicrobial resistance of Staphylococcus spp. isolated from clinical specimens in Hunan Province from 2012 to 2021, provide scientific basis for rational clinical antimicrobial use as well as the formulation and evaluation of management policies for clinical antimicrobial use. Methods According to China Antimicrobial Resistance Surveillance System (CARSS) technical scheme, antimicrobial resistance of Staphylococcus spp. reported by Hunan Province Antimicrobial Resistance Surveillance System in 2012-2021 was analyzed with WHONET 5.6 software. Results From 2012 to 2021, the top 4 isolated Staphylococcus were Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus haemolyticus and Staphylococcus hominis. Staphylococcus spp. were mainly isolated from specimens of sputum, blood, secretion, wound pus, and urine. Sputum and blood specimens accounting for 25.4%-31.8% and 21.9%-27.8%, respectively. Among all clinically isolated bacteria, Staphylococcus spp. accounted for 15.5%-22.4%, showing a slowly downward trend. In the past 10 years, detection rates of methicillin-resistant Staphylococcus aureus (MRSA) decreased from 35.1% to 24.8%, while detection rates of methicillin-resistant coagulase negative Staphylococcus (MRCNS) increased, but were lower than 70%. Susceptibility rates of Staphylococcus spp. to vancomycin, teicolanin and linezolid were 100%. Conclusion Among clinically isolated Staphylococcus spp. in Hunan Province, the detection rate of MRSA has decreased. Vancomycin-, teicoplanin- and linezolid-resistant Staphylococcus spp. were not found. Management of rational use of antimicrobial agents as well as prevention and control of healthcare-associated infection should be strengthened continuously, and antimicrobial resistance surveillance should be conducted well.

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邬靖敏,沈晖,伍勇,等.湖南省细菌耐药监测网2012—2021年葡萄球菌属细菌耐药性监测报告[J]. 中国感染控制杂志,2024,23(4):442-447. DOI:10.12138/j. issn.1671-9638.20245411.
Jing-min WU, Hui SHEN, Yong WU, et al. Antimicrobial resistance of Staphylococcus spp.: surveillance report from Hunan Province Antimicrobial Resistance Surveillance System, 2012-2021[J]. Chin J Infect Control, 2024,23(4):442-447. DOI:10.12138/j. issn.1671-9638.20245411.

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  • 收稿日期:2023-12-09
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  • 在线发布日期: 2024-06-24
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