Influenza is an acute respiratory infectious disease caused by influenza virus infection. After influenza virus invades the human body through the respiratory tract, the epithelial cells of the respiratory tract react first and produce a variety of cytokines to induce immune responses of human body. CC chemokines and CXC chemokines regulate a variety of immune cells in the process of influenza virus infection, and play important roles in the control of inflammatory response and maintenance of homeostasis in human body at the early stage of influenza virus infection. Analyzing the role of chemokines in regulating immune cells in host's body during the process of influenza virus infection can provide new strategies for treating against influenza. In this paper, the regulatory effects on various types of immune cells by CC and CXC chemokines as well as their related receptors during influenza virus infection are reviewed.