Clostridium perfringens is an important foodborne pathogen that causes intestinal infections and tissue necrosis in both human and animals. A variety of exotoxins it produces are lethal. The increasing demand for ratio-nal use of antimicrobial agents and healthy farming make the implementation of vaccination critically important. However, traditional Clostridium perfringens exotoxin vaccines may have problems such as inconsistent efficacy, residual toxins and formaldehyde, raising concerns about the safety of these vaccines. This article systematically introduces the latest research progress in traditional toxoid vaccine, genetically engineered recombinant vaccines, and epitope peptide vaccines designed based on reverse vaccinology and immunoinformatics for Clostridium perfringens, providing new ideas for the development and preparation of effective and safe novel Clostridium perfringens toxin vaccines.