Objective To explore and evaluate the micro-elimination mode of hepatitis C virus (HCV) in patients in a general hospital in Jiangxi Province, and provide reference for formulating provincial strategies to eliminate the public health hazards of HCV. Methods Relevant data of hospitalized patients who received HCV screening at the hospital from January 2021 to December 2022 were collected. Data from 2021 were set as the baseline and data from 2022 as the HCV micro-elimination mode operating data. Indexes such as gender, age, department, anti-HCV positive rate, HCV-RNA positive rate, etc. were analyzed. The operational effect was analyzed based on specialty department visiting rate, treatment rate, and loss-to-follow-up (LTFU) rate. The development of the mode was quantitatively evaluated by superiority weakness opportunity threats-analytic hierarchy process (SWOT-AHP) method. Results A total of 397 744 hospitalized patients underwent anti-HCV screening from 2021 to 2022, with a male to female ratio of 1.34 ∶1 and an average age of 54 years old. The main departments for patients receiving screening were infectious diseases/gastroenterology departments. HCV gene subtypes in specimens from 62 patients was mainly subtype 1b (43 specimens), followed by subtype 6 (9 specimens). The first HCV early warning rate after mode operation was 81.20%, the anti-HCV detection rate after warning was 93.15%, and the anti-HCV detection rate after subsequent pop-up window early warning was 100%. Compared with 2021, the treatment rate of HCV hospitalized patients in 2022 has increased, with statistically significant difference (P<0.05). However, there were no statistically significant differences in patients’ specialty department visiting rate and LTFU rate (both P>0.05). Barycentric coordinates calculation P (X, Y)=(0.018 2, 0.006 9) located in the first quadrant. Conclusion The HCV micro-elimination mode for patients in a general hospital in Jiangxi Province is feasible and effective. Further mode optimization should focus on strengths/opportunities (SO) strategy, to rely on internal advantages and utilize external opportunities.