Candida auris (C. auris) is a fungus with multidrug resistance. Current genomic studies indicate that C. auris shares similarities in genome size and evolution with other resistant yeast species. There are differences in genome size and structural variations among different geographical clades of C. auris, which may be related to differences in phenotype and drug resistance. C. auris exhibits resistance to multiple antifungal agents, including triazole, amphotericin B, and echinocandins. Genomic studies have found that resistance of C. auris may be related to factors such as membrane transport protein and mutation in the ergosterol pathway, its resistance can change further during evolution. In this paper, the relevant studies are reviewed, with a view to understanding the mechanism of drug resistance of C. auris, and providing important basis for formulating prevention and control strategies as well as treatment programs of C. auris.