Pasteurella multocida infection in humans is rare, and people with low immunity are susceptible to infection. This paper reports a case of an elderly woman bitten by a dog on her left calf. After routine emergency treatment, patient developed skin and soft tissue infection, presenting clinical manifestations of redness, swelling, heat, and pain around the wound, exudation of secretions, as well as blackness and necrosis of the surrounding tissues, etc, Pasteurella multocida infection was diagnosed according to secrection culture result and clinical manifestations. After amoxicillin/clavulanate potassium and surgical treatments, the patient recovered and was discharged. Based on literature review, this study discusses the clinical characteristics, laboratory examinations, and treatment of Pasteurella multocida infection, aiming to improve clinicians’ understanding on Pasteurella multocida, achieve early detection, diagnosis and treatment.