Objective To explore the clinical characteristics, antimicrobial resistance, virulence and molecular epidemiology characteristics of carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP). Methods Carbapenem-resistant Klebsiella pneumoniae (CRKP) strains isolated from clinical specimens in a tertiary first-class teaching hospital from 2018 to 2021 were collected. ST11 CR-hvKP strains were screened through the detection of antimicrobial resistance genes and virulence genes as well as multilocus sequence typing (MLST). Basic clinical information, antimicrobial resistance genes and virulence genes were analyzed. Twenty-three strains of ST11 CR-hvKP were randomly selected for virulence phenotype analysis; 45 strains of CR-hvKP were randomly selected for homology analysis by pulsed-field gel electrophoresis (PFGE). Results There were a total of 124 clinically isolated strains of ST11 CR-hvKP from 2018 to 2021, mainly from the department of neurosurgery (33.87%). The major specimen source was sputum (56.45%), the average age of infected patients were (55.2±16.4) years old, and the majority were male patients (77.42%). Antimicrobial susceptibility testing results showed these strains were resis-tant to most clinically commonly used antimicrobial agents. Virulence detection showed that virulence varied among these strains, but most of them were hypervirulence strains. PFGE analysis results showed that the strains were mainly subtype A1(63.4%). Conclusion ST11 CR-hvKP presents multidrug resistance and hypervirulence. Clonal transmission of some strains exists in this hospital, which poses great challenges for clinical anti-infection treatment as well as prevention and control. It is necessary to strengthen the prevention and control of healthcare-associated infection.