Antimicrobial resistance (AMR) has become a global public health crisis, posing a serious threat to the achievement of sustainable development goals (SDGs) of the United Nations. This article explores the potential consequences and far-reaching impacts of AMR on the global health system, economic development, and social well-being from the perspective of SDGs. This article analyzes the current situation and challenges of AMR prevention and control globally and domestically, proposes comprehensive response suggestions, such as establishing a global collaborative governance mechanism for AMR, deepening the "One Health" practice framework, perfecting survei-llance as well as infection prevention and control system on AMR, accelerating the development of new vaccines, exploring AMR innovative response technologies, and strengthening AMR literacy education for all people. The research findings can provide reference globally, especially for developing countries to comprehensively respond to the threat of AMR and promote the SDGs process.