The aging trend is intensifying currently, but there is still a lack of standardized diagnosis and treatment schemes for severe infections in elderly people. This paper focuses on the recommendations for immune-related clinical diagnosis and treatment routes as well as the idea of risk stratified diagnosis and treatment for elderly people, aiming to effectively prevent infectious diseases in elderly people and perform stratified management through systematic and scientific means of immune function monitoring and regulation, so as to enhance the standardized level of diagnosis and treatment as well as clinical treatment effect of infection in elderly people.