Objective To analyze the global literatures related to Chikungunya fever (CHIKF), explore the research status, hotspots, and frontiers of CHIKF, and provide reference for researchers and clinical workers. Methods CHIKF-related literatures were retrieved from PubMed from 2010 to 2025. Bibliometrix and VOSviewer software were used for visualization analysis. Results From 2010 to 2025, a total of 834 CHIKF-related literatures were retrieved. The annual publication volume presented a fluctuating upward trend. The journal with the highest publication volume was PLoS Neglected Tropical Diseases (n=25, 3.00%). The institution with the highest publication volume was The University of Texas Medical Branch (n=36). The countries with the highest publication volume were Brazil (31.59%), India (15.52%), and the United States (10.43%). The countries with the top three citation rates were the United States (n=836), Brazil (n=671), and India (n=568). 20.86% of the literatures had international cooperation, with the United States being the country with the most international cooperation. The keywords have shifted from "Chikungunya virus" "infection" "vector aedes" and "molecular biology mechanism" during the period of 2010-2020 to "Chikungunya virus" "vector mosq uito (Aedes aegypti)" "immunity and vector control" "related diseases (dengue fever)" "vaccines", etc. during the period of 2021-2025. Conclusion The attention to CHIKF-related research continues to increase, and research direction is shifting from basic research to clinical applications. The development of antiviral drugs and vaccines may become a future focus. Strengthening international cooperation and optimizing resource allocation will be the key points to promoting the prevention and control of CHIKF.