Objective To analyze the clinical characteristics of children with Chikungunya fever (CHIKF), and provide basis for the treatment and prevention of CHIKF in children. Methods Medical records of children under 14 years old with CHIKF admitted to Foshan Shunde District Le Cong Hospital from July 12 to August 17, 2025 were analyzed retrospectively.Epidemiological data, clinical characteristics, laboratory testing results, treatment methods of children were obtained through reviewing electronic health records. Results A total of 343 children confirmed with CHIKF were included in the analysis, all of whom resided in Foshan City, Guangdong Province. 198 were males (57.73%) and 145 were females (42.27%). The average age of children was (8.6±3.3) years old. The main initial symptoms were fever (n=302, 88.05%), rash (n=306, 89.21%), and joint pain (n=246, 71.72%). The initial laboratory testing results after admission showed that 95 cases (27.70%) had abnormal white blood cell count in blood routine, 3 cases (0.87%) had decreased platelets, 52 cases (15.16%) had increased C-reactive protein, and 87 cases (25.36%) reported Chikungunya virus nucleic acid CT values. All children were discharged after completing a 7-day quarantine or Chikungunya virus nucleic acid testing result turned negative, with no severe illness or death. Conclusion All cases from this epidemic experienced mild CHIKF. Early detection, early diagnosis, and early treatment are beneficial for reducing the occurrence of complications, and all children have good prognoses.