Hypervirulent Klebsiella pneumoniae (hvKP) exhibits unique phenotypes (such as hypermucoviscosity, specific serotypes) and genotypes (such as carrying specific virulence genes), demonstrating strong clinical pathogenicity. With the bacterial convergence evolution, the emergence of hypervirulent carbapenem-resistant Klebsiella pneumoniae (HCKP) poses significant challenges to global public health, as well as to clinical infection treatment and prevention. Early identification, timely diagnosis and treatment, as well as prevention and control of HCKP infection are crucial needs. This consensus aims to provide expert recommendations on the epidemiology, pathogenicity, antimicrobial resistance, clinical characteristics, laboratory testing, as well as prevention and control of HCKP, serving as a reference for diagnosis, treatment, as well as prevention and control of HCKP infections.