Objective To explore the clinical efficacy of hypochlorous acid in promoting postoperative wound hea-ling and reducing surgical site infection (SSI). Methods Hospitalized patients from the Department of Foot and Ankle Surgery in a tertiary first-class hospital were included in the analysis and grouped according to surgery sequence: patients from the first stage (October 16 to December 16, 2024) were taken as the control group, and iodophor (4 500-5 500 mg/L) was used for their postoperative wound disinfection; patients from the second stage (December 17, 2024 to February 17, 2025) were taken as the trial group, whose surgical wounds were disinfected with hypochlorous acid (110±16.5 mg/L). On the 1st, 3rd, 5th, 7th, 10th, and 14th days post-operation, wounds were disinfected, indicators were evaluated and recorded. The main outcome indicator was surgical site infection, while secondary indicators included postoperative 48-hour redness and swelling, allergy, and pain severity scores. Results The control group showed an infection incidence of 0.96%, an incidence of postoperative 48-hour redness and swelling of 16.99%, and a pain score of (1.41±0.49) point. In the trial group, no infections occurred, the incidence of postoperative 48-hour redness and swelling was 9.58%, and the pain score was (1.36±0.48) point. There were no statistically significant differences in the incidence of infection and pain score between the two groups (both P>0.05), but the difference in the incidence of redness and swelling was statistically significant (P=0.006). Stratified analysis by wound types revealed that in the open trauma subgroup, the incidence of infection in the control group was 3.19%, the incidence of redness and swelling was 29.79%, and the pain score was (1.62±0.49) point; while the incidence of postoperative 48-hour redness and swelling in the trial group was 8.14%, with a pain score of (1.41±0.49) point. There was no statistically significant difference in the incidence of infection between the two groups (P>0.05), while differences in the incidences of redness and swelling (P<0.001) as well as pain severity score (P=0.005) were statistically significant. In the closed traumatic injury subgroup, there were no statistically significant differences in all outcome indicators between groups (all P>0.05). Conclusion The application efficacy of hypochlorous acid solution in wound healing after closed traumatic injuries is comparable to that of iodophor. In open traumatic injuries, hypochlorous acid demonstrates superior effectiveness in controlling postoperative redness and swelling as well as pain compared to iodophor.