Airborne spread of infectious respiratory particles is a significant factor for healthcare-associated infection (HAI). Personnel activities within hospitals, such as personnel movements as well as operations of door-ope-ning and door-closing, can further increase the risk of infection. Therefore, it is necessary to study the effects of physical behaviors of personnel in medical buildings on the spread of infectious respiratory particles, so as to optimize medical procedures, improve building ventilation design, as well as enhance prevention and control systems. This paper systematically reviews the research progresses at home and abroad on how personnel movements as well as door-opening and door-closing behaviors influence the spread of infectious respiratory particles, analyzes current challenges, and looks forward to the future development directions, aiming to provide scientific basis for developing a more efficient HAI prevention and control system.