ObjectiveTo observe the adverse drug reactions of ganciclovir in treating infants with cytomegalovirus (CMV) hepatitis, and to analyse the influencing factors. MethodsInformation of the infants who suffered from CMV hepatitis and administered with ganciclovir from January,2005 to December, 2009 was collected, and the incidence of adverse reactions was calculated. The SPSS statistical software was used to analyse the influencing factors.ResultsThe total incidence of adverse reactions during the treatment of ganciclovir was 29.46%（71/241, 95%CI: 23.70%-35.21%）,the incidence of bone marrow suppression was 22.08%（51/231，95%CI: 16.73%-27.43%）, and the incidence of liver damage was 9.71 % (20/206, 95%CI: 5.67%-13.75%). Among 71 infants with adverse reaction , 46(64.79%)had effective treatment of ganciclovir; among 170 infants without adverse reaction, 120(70.59%) had effective treatment of ganciclovir, there was no significant difference in effective rate between two groups (χ2=0.79, P=0.38). There was no correlation between adverse reaction and infants’ genders, jaundice, premature delivery, cesarean section,and infection (all P>0.05).ConclusionGanciclovir can induce the bone supression and liver damage, but the treatment effect is not affected, there is no correlated influencing factor with adverse reaction.