ObjectiveTo investigate therapeutic effect of interventional injecting medicines through fiberbronchoscope on multidrug resistant cavernous pulmonary tuberculosis (MDRTB).MethodsEightsix patients (treatment group) with cavernous pulmonary MDRTB were treated with both injecting levofloxacin, amikacin, isoniazid, pyrazinamide through fiberbronchoscope catheter and routine chemotherapy, 94 cases in the control group were only given routine general chemotherapy. ResultsAfter 1,3,6 months treatment, the sputum negative conversion rate in treatment group was 17.44%, 65.11% and 87.21% respectively, which were significantly higher than those in control group（0.00%， 30.85% and 55.32%）respectively（P＜0.01）. After 3 months treatment, the effective rate in treatment group was 95.35%, cavity closure rate was 38.37%; which were significantly higher than those in control group (58.51% and 13.83%) respectively (P＜0.01）. ConclusionThe therapeutic effect of MDRTB treated with intervention injecting drugs in cavity by fiberbronchoscope and routine chemotherapy is superior to only routine chemotherapy.