ObjectiveTo evaluate the  measures for preventing and treating pulmonary infection in patients with  severe craniocerebral injury after tracheotomy. MethodsBy prospective and retrospective  analysis, clinical intervention measures (use of tracheal tube which can be rinsed, pay attention to the extraction of  tracheal tube, active bronchial lavage treatment through fiberbronchoscope, rational nutritional support and regulation of metabolism, sputum excretion by vibrative saliva ejector) were taken according to risk factors of  pulmonary infection after tracheotomy.ResultsIn observation group (clinical interventions were taken), pulmonary infection rate  in patients was 55.56%(35/63), the average time for controlling infection was (6.33±2.71)d; In control group (clinical interventions were not taken, retrospective  analysis), pulmonary infection was 72.31%(47/65), the average time for controlling infection was (8.44±3.14)d; There were significant difference in pulmonary infection rate and time for controlling infection between two groups (χ2=3.89, P<0.05; t=3.19，P<0.01, respectively). ConclusionAfter clinical interventions were taken, pulmonary infection in patients with  severe craniocerebral injury after tracheotomy reduced obviously, and time for controlling infection was also shortened.