ObjectiveTo investigate an outbreak  of handfootmouth disease (HFMD) caused by EV71 virus in a kindergarten of Fangshan district in Beijing,  the cause of outbreak  and the effective preventive measures of HFMD were analysed and evaluated. MethodsAll cases were performed epidemiological investigation based on the “questionnaire of case for HFMD” made by the Ministry of Health, the data were analyzed by descriptive study. ResultsThe group of low age children (2~3 years old) accounted for 87.50%(14/16) of all cases in this epidemic outbreak, the peak  of incidence was on May 13 and May 14, 2008; 6 cases isolated EV71 virus. ConclusionThe HFMD can easily  cause  outbreak  among low age children in kindergarten,   timely and effective control measures can prevent the HFMD outbreak caused by EV71 virus.