The prophylactic antimicrobial application for preventing surgical site infection of cesarean section: A Meta analysis
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R969.3

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    Abstract:

    ObjectiveTo evaluate the impact of prophylactic administration of antimicrobials in cesarean section on controlling surgical site infection (SSI) and  postpartum endometritis. MethodsComprehensive Chinese randomized controlled trials retrieval about preventing postpartum infection related to cesarean section by antimicrobial prophylactic use was performed via searching electronic database, hand searching bibliographies of books and relevant journals. ResultsCompared with longterm antimicrobial prophylaxis started after operation,  shortterm antimicrobial prophylaxis started 0.5~2 hours before operation or started after clamping of umbilical cord showed lower SSI rate (OR=0.34,95%CI 0.24~0.48,P<0.05) and puerperal morbidity (OR=0.40,95%CI 0.32~0.48,P<0.05), and there was no significant difference in lowering postpartum endometritis incidence between  selective cesareansection (OR=0.45,95%CI 0.11~1.83,P>0.05) and selective/unselective cesareansection (OR=0.55,95%CI 0.16~1.96,P>0.05). ConclusionShortterm antimicrobial prophylaxis started 0.5 to 2 hours before operation or after clamping of umbilical cord is a recommendable strategy for preventing SSI and puerperal morbidity.

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高斌,陈静,等.抗菌药物预防剖宫产手术部位感染国内文献荟萃分析[J].中国感染控制杂志英文版,2009,8(3):173-177.
GAO Bin, CHEN Jing, et al.
The prophylactic antimicrobial application for preventing surgical site infection of cesarean section: A Meta analysis[J]. Chin J Infect Control, 2009,8(3):173-177.

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History
  • Received:January 05,2009
  • Revised:March 22,2009
  • Adopted:
  • Online: May 30,2009
  • Published: