ObjectiveTo prepare  inorganic   lanthanumdoped titanium （LaTiO2 ） compounds, and observe the antibacterial activity on Staphylococcus aureus (ATCC 6538). MethodsThe six level samples of TiO2 were prepared by solgel method. The energy spectrometer technology was used to characterize these products. Antibacterial activity of 6  samples on Staphylococcus aureus were evaluated. Flask Shaking test was used to evaluate the best antibacterial activity among 6 samples; tube test method was used to determine the minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) of sample (code designation was FH1) with the best antibacterial activity in dark condition. Change in  bacterial ultrastructure was observed by electronmicroscope before and after the action of FH1 for 30 minutes. ResultsThe serials compounds without any foreign materials could be gotten with solgel technique,sample 1（FH1） had the best antibacterial activity. The MIC and MBC of FH1 for Staphylococcus aureus was 12.5mg/mL and 25mg/mL respectively. The  ultrastructure of  Staphylococcus aureus changed after exposed to FH1. ConclusionLaTiO2  compounds has good disinfection efficacy on Staphylococcus aureus.