ObjectiveTo summarize and analyze the incidence of occupational exposure to bloodborne pathogens among medical personnel, so as to provide strategies of prevention. MethodsA total of 48 cases of occupational exposure were analyzed retrospectively from 2003 to 2008.ResultsOf 48 occupational exposure cases, 19 were human immunodeficiency virus exposure, 18 were hepatitis B virus, 6 were hepatitis C virus, and 5 were Treponema pallidum exposure. Twentynine exposure were in medical personnel in operating room, 16 were in nonoperating room, 3 were in the other departments. Sharp injuries during operation were the most common route of exposure (16 cases). Most exposures were among doctors(24 cases, 4 of whom were interns), followed by nursing staff (21 cases, 8 of whom were probationer nurses), laboratorians(2 cases),and midwife (1 case). Intervention was carried out promptly among medical personnel after exposure , and no one was infected by these pathogens.ConclusionOccupational safety awareness should be emphasized，intervention should be taken promptly to reduce the risk of infection from postoccupational exposure.