ObjectiveTo realize the efficacy of practicing of preventive intervention measures of catheterassociated nosocomial infection（NI）in intensive care units (ICUs).MethodsTargeted surveillance was adopted to monitor the occurrence of NI in patients admitted in ICUs between January 2006- December 2007 and January 2008- December 2009 , corresponding intervention measures on NI were undertaken, NI rates were adjusted with average severity of illness score (ASIS) method . ResultsAfter adjusted with ASIS method ,the daily NI rate decreased from 5.77 ‰ between 2006-2007 to 3.63 ‰ between 2008-2009 ; catheterassociated infection rates decreased with different degree, ventilatorassociated pneumonia in surgical ICU decreased mostly， from 10.53 ‰ between 2006-2007 to 4.79‰ between 2008-2009.ConclusionCarrying out preventive intervention measures in ICUs can decrease NI rates obviously．