ObjectiveTo investigate the clinical characteristics  of surgical site infection(SSI) in a hospital ,so as  to reduce infection rate by making  appropriate prevention and control measures .MethodsSurveillance information of SSI in  patients from January 2006 to December 2009 was analysed prospectively.ResultsA total of 22 237 patients with surgical operations were monitored , 325(1.46%)  of whom developed SSI； The top three departments with infection rates were  urologic department(2.69%), orthopedics department(2.20%), and thoracic department(1.97%); The main isolated bacteria were Klebsiella pneumoniae(19.29%), Escherichia coli(17.26%) and Staphylococcus aureus(10.66%). ConclusionMonitoring  on departments with high risk factors and  main pathogens of  SSI should be intensified , intervention   measures for SSI should be adopted , and   the incidence of SSI can be reduced effectively.