Lamivudine combined with adefovir dipivoxil for treating entecavirrefractory chronic hepatitis B:one case report
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R512.6+2

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    Abstract:

    ObjectiveTo explore the treatment strategy for entecavirrefractory chronic hepatitis B (CHB) patients.MethodsOne entecavirrefractory CHB patient was switched to combination treatment of lamivudine with adefovir dipivoxil, and levels of HBV DNA and serum alanine transaminase (ALT) were followed up.ResultsAfter one year combined treatment , patient’s serum HBV DNA level dropped to 1.19×103IU/mL from the initial top of 2.02×108IU/mL and ALT level was recovered to normal range (≤40 U/L). ConclusionThe combination use of lamivudine with adefovir dipivoxil is effective for this entecavirrefractory CHB patient , but whether the treatment can be popularized needs to be further investigated.

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赵攀,韩玉坤,管群,等.拉米夫定联合阿德福韦酯治疗恩替卡韦初治无应答慢性乙型肝炎1例[J].中国感染控制杂志英文版,2011,10(4):266-268.
ZHAO Pan, HAN Yukun, GUAN Qun, et al. Lamivudine combined with adefovir dipivoxil for treating entecavirrefractory chronic hepatitis B:one case report[J]. Chin J Infect Control, 2011,10(4):266-268.

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History
  • Received:December 26,2010
  • Revised:February 13,2011
  • Adopted:
  • Online: July 30,2011
  • Published: